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The safety of stevia extracts has been confirmed by various toxicity, mutagenicity, and other studies.
The specification for stevia extracts is included in the Japan's Specifications and Standards for Food Additives 8th edition. It is specified therein that stevia extracts contain not less than 80.0% of the steviol glucoside base. Metabolism, absorption, and excretion study
E.Koyama., K.Kitasawa., Y.Ohori., O.Izawa., K.Kakegawa., A.Fujino & M.Ui., In vitro metabolism of glycosidic sweeteners, stevia mixture and enzymatically modified stevia in human intestinal microflora. Food and Chemical Toxicology Volume 41, Issue 3, March 2003, Pages359-374 Eriko Koyama., Norifumi Sakai., Yuji Ohori., Ken Kitazawa., Osamu Izawa., Kunio Kakegawa., Akiharu Fujino., Michio Ui., Absorption and metabolism of glycosidic sweeteners of stevia mixture and their aglycone, steviol, in rats and humans. Food and Chemical Toxicology Volume 41, (2003) 875-883 Acute toxicity study
Toskulkao, C., Chaturat, L., Temcharoen, P. & Glinsukon, T. Acute toxicity of stevioside, a natural sweetener, and its metabolite, steviol, in several animal species. Drug Chem. Toxicol., 20, 31|44.(1997) Subchronic toxicity study
"Aze, Y., Toyoda, K., Imaida, K., Hayashi, S., Imazawa, T., Hayashi, Y., & Takahashi, M.
Subchronic oral toxicity study of stevioside in F344 rats. Bull. Natl Inst. Hyg. Sci., 48|54 (1991),(in Japanese)." Chronic toxicity and carcinogenicity study
"Toyoda, K., Matsui, H., Shoda, T., Uneyama, C., Takada, K. & Takahashi, M.
Assessment of the carcinogenicity of stevioside in F344 rats.
Food Chem. Toxicol., 35, 597|603.(1997)" "Xili, L., Chengjiany, B., Eryi, X., Reiming, S., Yuengming, W., Haodong, S. & Zhiyian, H. (1992)
Chronic oral toxicity and carcinogenicity study of stevioside in rats.
Food Chem. Toxicol., 30, 957|965." Mutagenicity study
Kaoru Sekihashi., Hiromi Saitoh & Yu F. Sasaki., Genotoxicity studies of stevia extract and steviol by the comet assay. The Journal of Toxicological Sciences, Vol 27, Supplement I, 1-8, 2002 (Japanese) Madoka Nakajima et al., Micronucleus test of rebaudioside A in mice. Biosafety research center, Foods, Drugs and Pestcides 2000 (Japanese) Madoka Nakajima et al., Chromosome aberration assay of rebaudioside A in cultured mammalian cells. Biosafety research center, Foods, Drugs and Pesticides 2000 (Japanese) Teratogenicity study
"Usami, M., Sakemi, K., Kawashima, K., Tsuda, M. & Ohno, Y. (1995) Teratogenicity study
of stevioside in rats. Bull. Natl Inst. Hyg. Sci., 113, 31|35 ( in Japanese )" Reproduction toxicity study
Akashi.Haruo, Yokoyama.Yukio, Dried-leaf extracts of stevia. Toxicological tests Shokuhin Kogyo. 1975 18; 34-43 (Japanese) Mori, N., Sakanoue, M., Takeuchi, M., Shimpo, K. & Tanabe, T. (1981) Effect of stevioside on fertility in rats. J. Food Hyg. Soc. Jpn., 22, 409|414 (in Japanese)
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